Buprenorphine is used for:
Buprenorphine is a narcotic analgesic. It works by working in the brain and nervous system to decrease pain.
Do NOT use buprenorphine if:
- you are allergic to any ingredient in buprenorphine
- you are taking sodium oxybate (GHB)
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Before using buprenorphine:
Some medical conditions may interact with buprenorphine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of blood or electrolyte problems, breathing or lung problems (eg, chronic obstructive pulmonary disease), underactive thyroid, adrenal gland problems (eg, Addison disease), liver or kidney problems, an enlarged prostate gland, trouble urinating, a blockage of your bladder or urethra, gallbladder problems, or stomach problems
- if you have a history of recent head injury, growths in the brain (eg, tumor), or increased pressure in the brain, or muscle problems (eg, myasthenia gravis)
- if you have a history of mental or mood problems, drug or alcohol abuse, or if you have a physical dependence on narcotic medicines (eg, morphine) or other opiates (eg, heroin)
- Azole antifungals (eg, ketoconazole), HIV protease inhibitors (eg, ritonavir), or macrolide antibiotics (eg, erythromycin) because the side effects of buprenorphine may be increased
- Benzodiazepines (eg, diazepam), cimetidine, narcotic pain medicine (eg, codeine), phenothiazines (eg, chlorpromazine), or sodium oxybate (GHB) because the risk of severe drowsiness, severe breathing problems, and seizures may be increased
- Naltrexone or rifampin because the effectiveness of buprenorphine may be decreased
- Methadone because effectiveness may be decreased by buprenorphine
This may not be a complete list of all interactions that may occur. Ask your health care provider if buprenorphine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

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